概述

  • 产品名称Anti-SENP3抗体
    参阅全部 SENP3 一抗
  • 描述
    兔多克隆抗体to SENP3
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide from an internal region of Human SENP3

  • 阳性对照
    • Human breast carcinoma tissue

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab58419 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/10000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
  • 序列相似性Belongs to the peptidase C48 family.
  • 细胞定位Cytoplasm. Nucleus > nucleolus. Nucleus > nucleoplasm. Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress.
  • Information by UniProt
  • 数据库链接
  • 别名
    • SENP3 antibody
    • SENP3_HUMAN antibody
    • Sentrin / SUMO specific protease 3 antibody
    • Sentrin specific protease 3 antibody
    • Sentrin-specific protease 3 antibody
    • Sentrin/SUMO-specific protease SENP3 antibody
    • SMT3IP1 antibody
    • SSP3 antibody
    • SUMO 1 specific protease 3 antibody
    • SUMO-1-specific protease 3 antibody
    • SUMO1 specific protease 3 antibody
    • SUMO1/sentrin/SMT3 specific peptidase 3 antibody
    • SUSP3 antibody
    see all

Anti-SENP3 antibody 图像

  • Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue with ab58419 at 1/50 dilution, in the absence or presence of the immunizing peptide peptide.

Anti-SENP3 antibody (ab58419)参考文献

ab58419 has not yet been referenced specifically in any publications.

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