概述

  • 产品名称Anti-SENP2抗体[EPR4356(2)]
    参阅全部 SENP2 一抗
  • 描述
    兔单克隆抗体[EPR4356(2)] to SENP2
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    A synthetic peptide corresponding to residues in Human SENP2.

  • 阳性对照
    • MDA-MB-435, NIH:OVCAR-3, and 293T cell lysates; Human colon tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab124724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/50000. Detects a band of approximately 68 kDa (predicted molecular weight: 68 kDa).
IHC-P 1/500 - 1/1000. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ICC/IF 1/250 - 1/500.
  • 应用说明Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
    • 序列相似性Belongs to the peptidase C48 family.
    • 结构域The N-terminus is necessary and sufficient for nuclear envelope targeting.
    • 翻译后修饰Polyubiquitinated; which leads to proteasomal degradation.
    • 细胞定位Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Axam2 antibody
      • DKFZp762A2316 antibody
      • KIAA1331 antibody
      • Senp2 antibody
      • SENP2_HUMAN antibody
      • Sentrin specific protease 2 antibody
      • Sentrin-specific protease 2 antibody
      • Sentrin/SUMO specific protease SENP2 antibody
      • Sentrin/SUMO-specific protease SENP2 antibody
      • SMT3 specific isopeptidase 2 antibody
      • SMT3-specific isopeptidase 2 antibody
      • Smt3ip2 antibody
      • SUMO1/sentrin/SMT3 specific peptidase 2 antibody
      see all

    Anti-SENP2 antibody [EPR4356(2)] 图像

    • ab124724, at 1/500 dilution, staining SENP2 in paraffin embedded Human colon tissue by immunohistochemistry.
    • All lanes : Anti-SENP2 antibody [EPR4356(2)] (ab124724) at 1/10000 dilution

      Lane 1 : MDA-MB-435 cell lysate
      Lane 2 : NIH:OVCAR-3 cell lysate
      Lane 3 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size : 68 kDa

    Anti-SENP2 antibody [EPR4356(2)] (ab124724)参考文献

    This product has been referenced in:

    See 1 Publication for this product

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