Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway.
Belongs to the peptidase C48 family.
The N-terminus is necessary and sufficient for nuclear envelope targeting.
Polyubiquitinated; which leads to proteasomal degradation.
Nucleus > nuclear pore complex. Nucleus membrane. Cytoplasm. Shuttles between cytoplasm and nucleus.
Detection of SENP2 by Western Blot of Immunprecipitate.
ab109590 at 1µg/ml staining SENP2 in HeLa whole cell lysate immunoprecipitated using ab109590 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 30 seconds.