概述

  • 产品名称Anti-Seladin 1抗体
    参阅全部 Seladin 1 一抗
  • 描述
    兔多克隆抗体to Seladin 1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 431-480 (AELYIDIGAY GEPRVKHFEA RSCMRQLEKF VRSVHGFQML YADCYMNREE) of Human Seladin 1 (NP_055577).

  • 阳性对照
    • THP1 cell lysate

应用

Our Abpromise guarantee covers the use of ab98345 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 60 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
  • 组织特异性Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
  • 通路Steroid biosynthesis; cholesterol biosynthesis.
  • 疾病相关Desmosterolosis (DESMOS) [MIM:602398]: Rare autosomal recessive disorder characterized by multiple congenital anomalies and elevated levels of the cholesterol precursor desmosterol in plasma, tissue, and cultured cells. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • 序列相似性Belongs to the FAD-binding oxidoreductase/transferase type 4 family.
    Contains 1 FAD-binding PCMH-type domain.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 24 dehydrocholesterol reductase antibody
    • 24-dehydrocholesterol reductase antibody
    • 3 beta hydroxysterol delta 24 reductase antibody
    • 3-beta-hydroxysterol delta-24-reductase antibody
    • DCE antibody
    • Delta(24)-sterol reductase antibody
    • Desmosterol to cholesterol enzyme antibody
    • DHC24_HUMAN antibody
    • Dhcr24 antibody
    • Diminuto dwarf1 homolog antibody
    • Diminuto/dwarf1 homolog antibody
    • KIAA0018 antibody
    • Nbla03646 antibody
    • Seladin-1 antibody
    • SELADIN1 antibody
    • Selective AD indicator 1 antibody
    • Selective Alzheimer's Disease Indicator 1 antibody
    see all

Anti-Seladin 1 antibody 图像

  • Anti-Seladin 1 antibody (ab98345) at 1 µg/ml + THP1 cell lysate at 10 µg

    Predicted band size : 60 kDa

Anti-Seladin 1 antibody (ab98345)参考文献

ab98345 has not yet been referenced specifically in any publications.

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