Anti-Secretory Component Glycoprotein抗体[SPM217] (ab17921)

概述

  • 产品名称Anti-Secretory Component Glycoprotein抗体[SPM217]
    参阅全部 Secretory Component Glycoprotein 一抗
  • 描述
    小鼠单克隆抗体[SPM217] to Secretory Component Glycoprotein
  • 经测试应用适用于: ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Full length native protein (purified) (Human).

  • 表位Not determined
  • 阳性对照
    • Small intestine. Colon carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab17921 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
IHC-P
  • 应用说明
    IF: Use at an assay dependent dilution.
    IHC-P: 1/50. Perform enzymatic antigen retrieval before commencing with IHC staining protocol. For staining of formalin-fixed tissues, digest sections with trypsin at 1mg/ml PBS, 15 min at room temp.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    • 组织特异性Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
    • 疾病相关Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ECM 1 antibody
      • Ecm1 antibody
      • ECM1_HUMAN antibody
      • Extracellular matrix protein 1 antibody
      • Secretory component p85 antibody
      • URBWD antibody
      see all

    Anti-Secretory Component Glycoprotein antibody [SPM217] 图像

    • Human colon carcinoma stained with ab17921.

    Anti-Secretory Component Glycoprotein antibody [SPM217] (ab17921)参考文献

    ab17921 has not yet been referenced specifically in any publications.

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