Anti-Secretory Component Glycoprotein抗体[COMPO2], prediluted (ab75232)

概述

  • 产品名称Anti-Secretory Component Glycoprotein抗体[COMPO2], prediluted
    参阅全部 Secretory Component Glycoprotein 一抗
  • 描述
    小鼠单克隆抗体[COMPO2] to Secretory Component Glycoprotein, prediluted
  • 特异性ab75232 reacts with both free and polymeric Ig-bound Secretory Component Glycoprotein.
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Full length native Secretory Component Glycoprotein (semi-purified) (Human)

  • 阳性对照
    • Stomach, small intestine, colon carcinoma.
  • 常规说明Clone designation COMPO2 is the same as SC-05.

性能

应用

Our Abpromise guarantee covers the use of ab75232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: Ready-to-use. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity.
    • 组织特异性Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
    • 疾病相关Defects in ECM1 are the cause of lipoid proteinosis (LiP) [MIM:247100]; also known as lipoid proteinosis of Urbach and Wiethe or hyalinosis cutis et mucosae. LiP is a rare autosomal recessive disorder characterized by generalized thickening of skin, mucosae and certain viscera. Classical features include beaded eyelid papules and laryngeal infiltration leading to hoarseness. Histologically, there is widespread deposition of hyaline material and disruption/reduplication of basement membrane.
    • 细胞定位Secreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ECM 1 antibody
      • Ecm1 antibody
      • ECM1_HUMAN antibody
      • Extracellular matrix protein 1 antibody
      • Secretory component p85 antibody
      • URBWD antibody
      see all

    Anti-Secretory Component Glycoprotein antibody [COMPO2], prediluted 图像

    • Formalin-fixed, paraffin-embedded human colon carcinoma stained with ab75232, using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

    Anti-Secretory Component Glycoprotein antibody [COMPO2], prediluted (ab75232)参考文献

    ab75232 has not yet been referenced specifically in any publications.

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