Anti-SCRIBBLE抗体[EPR4140(2)] (ab125080)


  • 产品名称Anti-SCRIBBLE抗体[EPR4140(2)]
    参阅全部 SCRIBBLE 一抗
  • 描述
    兔单克隆抗体[EPR4140(2)] to SCRIBBLE
  • 经测试应用适用于: WB, ICC, Flow Cytmore details
    不适用于: IHC-P or IP
  • 种属反应性
    与反应: Human
    不与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide, corresponding to residues near the C-terminus of Human SCRIBBLE.

  • 阳性对照
    • 293T, HeLa and MCF7 cell lysates; permeabilized 293T cells.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.



Our Abpromise guarantee covers the use of ab125080 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Detects a band of approximately 250 kDa (predicted molecular weight: 175 kDa).
ICC 1/100 - 1/250.
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

  • 应用说明Is unsuitable for IHC-P or IP.
  • 靶标

    • 功能Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
    • 组织特异性Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
    • 序列相似性Belongs to the LAP (LRR and PDZ) protein family.
      Contains 16 LRR (leucine-rich) repeats.
      Contains 4 PDZ (DHR) domains.
    • 翻译后修饰Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
    • 细胞定位Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CRIB 1 antibody
      • CRIB1 antibody
      • hScrib antibody
      • LAP 4 antibody
      • LAP4 antibody
      • PDZ domain protein scribble antibody
      • Protein LAP4 antibody
      • Protein scribble homolog antibody
      • SCRB 1 antibody
      • SCRB1 antibody
      • SCRIB 1 antibody
      • Scrib antibody
      • SCRIB_HUMAN antibody
      • SCRIB1 antibody
      • Scribble antibody
      • Scribble homolog 1 antibody
      • scribbled homolog (Drosophila) antibody
      • Vartul antibody
      see all

    Anti-SCRIBBLE antibody [EPR4140(2)] 图像

    • All lanes : Anti-SCRIBBLE antibody [EPR4140(2)] (ab125080) at 1/1000 dilution

      Lane 1 : 293T cell lysate
      Lane 2 : HeLa cell lysate
      Lane 3 : MCF7 cell lysate

      Lysates/proteins at 10 µg per lane.

      Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size : 175 kDa
    • ab125080 at 1/100, staining SCRIBBLE in permeabilized 293T cells by flow cytometry (red), compared with a negative control Rabbit IgG antibody (green).

    Anti-SCRIBBLE antibody [EPR4140(2)] (ab125080)参考文献

    ab125080 has not yet been referenced specifically in any publications.

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