概述

  • 产品名称Anti-SCO2抗体
    参阅全部 SCO2 一抗
  • 描述
    兔多克隆抗体to SCO2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the C-terminus of Human SCO2.

  • 阳性对照
    • IHC-P: Human Lung, Respiratory Epithelium and Human Kidney tissues

性能

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应用

Our Abpromise guarantee covers the use of ab115877 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 30 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).
  • 组织特异性Ubiquitous.
  • 疾病相关Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC) [MIM:604377]. This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies.
  • 序列相似性Belongs to the SCO1/2 family.
    Contains 1 thioredoxin domain.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cytochrome oxidase deficient homolog 2 antibody
    • MGC125823 antibody
    • MGC125825 antibody
    • OTTHUMP00000196774 antibody
    • OTTHUMP00000196775 antibody
    • Protein SCO2 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient, yeast) homolog 2 antibody
    • SCO 1L antibody
    • SCO 2 antibody
    • SCO cytochrome oxidase deficient homolog 2 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 2 antibody
    • SCO1L antibody
    • SCO2 antibody
    • SCO2_HUMAN antibody
    • Synthesis of cytochrome c oxidase 2 antibody
    see all

Anti-SCO2 antibody 图像

  • Human Lung, Respiratory Epithelium (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Kidney (formalin-fixed, paraffin-embedded) stained with ab115877 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SCO2 antibody (ab115877)参考文献

ab115877 has not yet been referenced specifically in any publications.

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