概述

  • 产品名称Anti-SCO1抗体
    参阅全部 SCO1 一抗
  • 描述
    小鼠多克隆抗体to SCO1
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human protein (NP_004580.1)

  • 阳性对照
    • WB: lysate from Human liver or HeLa cells. ICC/IF: HepG2 cells.

性能

应用

Our Abpromise guarantee covers the use of ab88658 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 34 kDa.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • 组织特异性Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • 疾病相关Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 序列相似性Belongs to the SCO1/2 family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Anti-SCO1 antibody 图像

  • ab88658 at 10 µg/ml staining SCO1 by immunofluorescence in paraformaldehyde fixed, permeabilized HepG2 cells.
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + Human liver lysate at 50 µg

    Predicted band size : 34 kDa
  • Anti-SCO1 antibody (ab88658) at 1 µg/ml + HeLa cell lysate at 50 µg

    Predicted band size : 34 kDa
  • All lanes : Anti-SCO1 antibody (ab88658) at 1 µg/ml

    Lane 1 : SCO1 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 34 kDa
    Observed band size : 33 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 27 kDa. We are unsure as to the identity of these extra bands.

Anti-SCO1 antibody (ab88658)参考文献

ab88658 has not yet been referenced specifically in any publications.

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