概述

  • 产品名称Anti-SCO1抗体
    参阅全部 SCO1 一抗
  • 描述
    兔多克隆抗体to SCO1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to 19 amino acids from near the center of Human SCO1.

  • 阳性对照
    • IHC-P: Human Heart and Human Brain Cortex tissues

性能

应用

Our Abpromise guarantee covers the use of ab115873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 34 kDa.
IHC-P Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Thought to play a role in cellular copper homeostasis, mitochondrial redox signaling or insertion of copper into the active site of COX.
  • 组织特异性Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.
  • 疾病相关Defects in SCO1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • 序列相似性Belongs to the SCO1/2 family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cytochrome oxidase deficient homolog antibody
    • Cytochrome oxidase deficient homolog 1 antibody
    • Protein SCO1 homolog mitochondrial antibody
    • Protein SCO1 homolog, mitochondrial antibody
    • SCO (cytochrome oxidase deficient yeast) homolog 1 antibody
    • SCO cytochrome oxidase deficient homolog 1 (yeast) antibody
    • SCO cytochrome oxidase deficient homolog 1 antibody
    • sco1 antibody
    • SCO1_HUMAN antibody
    • SCOD1 antibody
    see all

Anti-SCO1 antibody 图像

  • Human Heart (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
  • Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with ab115873 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SCO1 antibody (ab115873)参考文献

ab115873 has not yet been referenced specifically in any publications.

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