概述

  • 产品名称
  • 描述
    兔多克隆抗体to SCNN1B
  • 特异性
    Detects recombinant rat beta-epithelial sodium channel (SCNN1B).
  • 经测试应用
    适用于: IP, IHC-Pmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Rabbit
  • 免疫原

    Synthetic peptide corresponding to Human SCNN1B aa 619-640.
    Sequence:

    NYDSLRLQPLDVIESDSEGDAI


    (Peptide available as ab4926)

性能

应用

Our Abpromise guarantee covers the use of ab2906 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.

By immunoprecipitation this antibody specifically binds to unglycosylated, ~75 kDa recombinant rat SCNN1B protein.

IHC-P Use at an assay dependent concentration.

靶标

  • 功能
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • 疾病相关
    Pseudohypoaldosteronism 1, autosomal recessive
    Liddle syndrome
    Bronchiectasis with or without elevated sweat chloride 1
  • 序列相似性
    Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1B subfamily.
  • 翻译后修饰
    Phosphorylated on serine and threonine residues.
  • 细胞定位
    Apical cell membrane. Apical membrane of epithelial cells.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Amiloride sensitive sodium channel subunit beta antibody
    • Amiloride-sensitive sodium channel subunit beta antibody
    • Beta NaCH antibody
    • Beta-ENaC antibody
    • Beta-NaCH antibody
    • ENaC beta antibody
    • ENaCB antibody
    • Epithelial Na(+) channel subunit beta antibody
    • Epithelial Na+ channel beta subunit antibody
    • Epithelial Na+ channel subunit beta antibody
    • Epithelial sodium channel beta 2 subunit antibody
    • Epithelial sodium channel beta 3 subunit antibody
    • Nonvoltage gated sodium channel 1 beta subunit antibody
    • Nonvoltage gated sodium channel 1 subunit beta antibody
    • Nonvoltage-gated sodium channel 1 subunit beta antibody
    • SCNEB antibody
    • SCNN 1B antibody
    • SCNN1B antibody
    • SCNNB_HUMAN antibody
    • Sodium channel nonvoltage gated 1 beta (Liddle syndrome) antibody
    • Sodium channel nonvoltage gated 1 beta antibody
    see all

文献

This product has been referenced in:
  • Yusef YR  et al. Estrogen increases ENaC activity via PKCd signaling in renal cortical collecting duct cells. Physiol Rep 2:N/A (2014). WB . Read more (PubMed: 24872356) »
  • Zhou Y  et al. Induction of renal 20-hydroxyeicosatetraenoic acid by clofibrate attenuates high-fat diet-induced hypertension in rats. J Pharmacol Exp Ther 317:11-8 (2006). Read more (PubMed: 16339392) »

See all 2 Publications for this product

客户评价及客户问答

Application
Western blot
Sample
Rat Tissue lysate - whole (Heart)
Gel Running Conditions
Reduced Denaturing (10)
Loading amount
40 µg
Specification
Heart
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
Username

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提交于 Apr 24 2015

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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