概述

  • 产品名称
    Anti-SCN3B抗体
  • 描述
    兔多克隆抗体to SCN3B
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Rat, Human
    预测可用于: Mouse, Cow
  • 免疫原

    A region within synthetic peptide: RPEGGKDFLI YEYRNGHQEV ESPFQGRLQW NGSKDLQDVS ITVLNVTLND, corresponding to amino acids 65-114 of Human SCN3B

  • 阳性对照
    • Fetal brain lysate.

性能

应用

Our Abpromise guarantee covers the use of ab48552 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 24 kDa (predicted molecular weight: 24 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • 疾病相关
    Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7) [MIM:613120]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 序列相似性
    Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 细胞定位
    Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110001K16Rik antibody
    • 4833414B02Rik antibody
    • HSA243396 antibody
    • KIAA1158 antibody
    • MGC136997 antibody
    • MGC80155 antibody
    • Scn3b antibody
    • SCN3B_HUMAN antibody
    • SCNB3 antibody
    • Sodium channel subunit beta-3 antibody
    • Sodium channel, beta 3 subunit antibody
    • sodium channel, voltage-gated, type III, beta antibody
    see all

图片

  • Anti-SCN3B antibody (ab48552) at 0.5 µg/ml + fetal brain lysate at 10 µg with 5% skimmed milk in PBS buffer

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 24 kDa
    Observed band size : 24 kDa

实验方案

文献

This product has been referenced in:
  • Shy D  et al. PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. Circulation 130:147-60 (2014). Read more (PubMed: 24895455) »
  • Ho C  et al. Differential expression of sodium channel ß subunits in dorsal root ganglion sensory neurons. J Biol Chem : (2012). WB ; Rat . Read more (PubMed: 22408255) »

See all 3 Publications for this product

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