概述

  • 产品名称Anti-SCN1B抗体
    参阅全部 SCN1B 一抗
  • 描述
    兔多克隆抗体to SCN1B
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A synthetic peptide corresponding to a sequence at the N-terminal of Human SCN1B

  • 阳性对照
    • Rat brain and testicular tissue lysates; MCF7, HeLa, MM231 and HT1080 whole cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab86931 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 25 kDa).

靶标

  • 功能Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons.
  • 组织特异性Abundantly expressed in skeletal muscle, heart and brain.
  • 疾病相关Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1) [MIM:604233]. Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity.
    Defects in SCN1B are the cause of Brugada syndrome type 5 (BRS5) [MIM:612838]. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
  • 序列相似性Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family.
    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • GEFSP1 antibody
    • SCN1B antibody
    • SCN1B_HUMAN antibody
    • sodium channel beta 1 subunit antibody
    • Sodium channel subunit beta 1 antibody
    • Sodium channel subunit beta-1 antibody
    • Sodium channel voltage gated type I beta antibody
    • Sodium channel voltage gated type I beta subunit antibody
    see all

Anti-SCN1B antibody 图像

  • All lanes : Anti-SCN1B antibody (ab86931) at 1 µg/ml

    Lane 1 : Rat brain tissue lysate
    Lane 2 : Rat testicular tissue lysate
    Lane 3 : MCF7 whole cell lysate
    Lane 4 : HeLa whole cell lysate
    Lane 5 : MM231 whole cell lysate
    Lane 6 : HT1080 whole cell lysate


    Predicted band size : 25 kDa
    Observed band size : 25 kDa

Anti-SCN1B antibody (ab86931)参考文献

ab86931 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 50 µg
Gel Running Conditions Non-reduced Non-Denaturing (Native)
Sample Rat Cell lysate - whole cell (cardiamyocyte)
Specification cardiamyocyte
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 0.05% · Temperature: RT°C
Username

Mr. Kuihao Chen

Verified customer

提交于 Dec 18 2013

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"