概述

  • 产品名称Anti-SCN11A抗体
    参阅全部 SCN11A 一抗
  • 描述
    小鼠单克隆抗体to SCN11A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: TTTKRKEEER GAAIIQKAFR KYMMKVTKGD QGDQNDLENG PHSPLQTLCN GDLSSFGVAK GKVHCD, corresponding to amino acids 1726-1792 of Human SCN11A

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2a
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab56959 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.
    • 组织特异性Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.
    • 疾病相关Neuropathy, hereditary sensory and autonomic, 7
      Episodic pain syndrome, familial, 3
    • 序列相似性Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.
    • 结构域The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.
    • 翻译后修饰Phosphorylation at Ser-1341 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • hNaN antibody
      • NaN antibody
      • NAV1.9 antibody
      • Peripheral nerve sodium channel 5 antibody
      • PN 5 antibody
      • PN5 antibody
      • SCN 11A antibody
      • SCN 12A antibody
      • Scn11a antibody
      • SCN12A antibody
      • SCNBA_HUMAN antibody
      • Sensory neuron sodium channel 2 antibody
      • SNS 2 antibody
      • SNS2 antibody
      • Sodium channel protein type 11 subunit alpha antibody
      • Sodium channel protein type XI subunit alpha antibody
      • Sodium channel voltage gated type XI alpha antibody
      • Sodium channel voltage gated type XI alpha polypeptide antibody
      • Sodium channel voltage gated type XI alpha subunit antibody
      • Sodium channel voltage gated type XII alpha polypeptide antibody
      • Voltage gated sodium channel Nav1.9 antibody
      • Voltage gated sodium channel subunit alpha Nav1.9 antibody
      • Voltage-gated sodium channel subunit alpha Nav1.9 antibody
      see all

    Anti-SCN11A antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56959 SCN11A antibody at 1ug/ml. Predicted band size of immunogen is 33 kDa

    Anti-SCN11A antibody (ab56959)参考文献

    ab56959 has not yet been referenced specifically in any publications.

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