功能Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.
组织特异性Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
序列相似性Contains 1 C-type lectin domain.
发展阶段In the bone marrow, expression is limited to immature neutrophils. Expression was not detected in circulating mature neutrophils.
翻译后修饰O-glycosylated. Probably sulfated on the O-glycans.