概述

  • 产品名称Anti-SCDGFB抗体
    参阅全部 SCDGFB 一抗
  • 描述
    兔多克隆抗体to SCDGFB
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cat
  • 免疫原

    Synthetic peptide from within N terminal amino acids 35-83: ANLRRDESNH LTDLYRRDET IQVKGNGYVQ SPRFPNSYPR NLLLTWRLHS, of Human SCDGFB (NP_079484)

  • 阳性对照
    • Human fetal heart lysate

性能

应用

Our Abpromise guarantee covers the use of ab94782 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 43 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Potent mitogen for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. Activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet-derived growth factor receptor. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis.
  • 组织特异性Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of arteriosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines.
  • 序列相似性Belongs to the PDGF/VEGF growth factor family.
    Contains 1 CUB domain.
  • 发展阶段Not detectable in the earliest stages of glomerulogenesis, and not detected in the metanephric blastema or surrounding cortical interstitial cells. In later stages of glomerulogenesis, localized to epithelial cells transitioning from the early developing nephrons of the comma- and S-shaped stages to the visceral epithelial cells of differentiated glomeruli. In the developing pelvis, expressed at the basement membrane of immature collecting ducts and by presumptive fibroblastic cells in the interstitium.
  • 翻译后修饰Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • IEGF antibody
    • Iris expressed growth factor antibody
    • Iris-expressed growth factor antibody
    • MGC26867 antibody
    • MSTP036 antibody
    • PDGF D antibody
    • PDGF-D antibody
    • PDGFD antibody
    • PDGFD latent form antibody
    • PDGFD receptor-binding form antibody
    • PDGFD_HUMAN antibody
    • Platelet derived growth factor D antibody
    • Platelet-derived growth factor D antibody
    • receptor-binding form antibody
    • rSCDGF-B antibody
    • SCDGF B antibody
    • SCDGF-B antibody
    • Spinal cord derived growth factor B antibody
    • Spinal cord-derived growth factor B antibody
    • spinal-cord derived growth factor-B protein antibody
    see all

Anti-SCDGFB antibody 图像

  • Anti-SCDGFB antibody (ab94782) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 43 kDa

Anti-SCDGFB antibody (ab94782)参考文献

ab94782 has not yet been referenced specifically in any publications.

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