概述

  • 产品名称Anti-SCC112抗体
    参阅全部 SCC112 一抗
  • 描述
    兔多克隆抗体to SCC112
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human SCC112 aa 1250-1297 (C terminal).
    Database link: 23244
    (Peptide available as ab40229)

性能

应用

Our Abpromise guarantee covers the use of ab17961 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/10000 - 1/25000. Detects a band of approximately 145 kDa (predicted molecular weight: 150 kDa).
IP Use a concentration of 1 - 4 µg/ml.

靶标

  • 功能Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
  • 组织特异性Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
  • 序列相似性Belongs to the PDS5 family.
    Contains 1 HEAT repeat.
  • 发展阶段Cell cycle-regulated with highest level in G2 phase.
  • 细胞定位Nucleus. Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cell proliferation inducing protein 54 antibody
    • Cell proliferation-inducing gene 54 protein antibody
    • KIAA0648 antibody
    • PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae) antibody
    • PDS5A antibody
    • PDS5A_HUMAN antibody
    • PIG54 antibody
    • SCC-112 antibody
    • SCC112 antibody
    • Sister chromatid cohesion protein 112 antibody
    • Sister chromatid cohesion protein PDS5 homolog A antibody
    see all

Anti-SCC112 antibody 图像



  • Predicted band size : 150 kDa


    Detection of Human SCC-112 by Western Blot and Immunoprecipitation.
    Lane 1: WB; 5 µg of NE
    Lane 2: WB; 20 µg of NE
    Lane 3: IP (with a different antibody) followed by WB; 1 mg of NE
    Lane 4: IP (with ab17961) followed by WB; 1 mg of NE 5 to 20µg of nuclear extract (NE) from HeLa cell lysate were used for WB. 1 mg of nuclear extract (NE) from HeLa cell lysate were used for IP.
    Detection: Chemiluminescence with an exposure time of less than 5 minutes.

    Ab17961 was used at a dilution of 1/10,000 for the western blot and 2 µg/mg of extract for immunoprecipitation.

Anti-SCC112 antibody (ab17961)参考文献

ab17961 has not yet been referenced specifically in any publications.

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