Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog, Pig
Synthetic peptide corresponding to a region within internal sequence amino acids 318-367 (PGMQESADKP TRRENPHKYL LYKPTFSQLY TFLAASFKEL PANSVLLIYL) of Human SCAI (NP_775961; UniProt ID: Q8N9R8 isoform 2).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 73 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
功能Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.
序列相似性Belongs to the SCAI family.
细胞定位Membrane. Nucleus. Cytoplasm. Nuclear localization is required for inhibition of MKL1.