SB 269970 hydrochloride (ab120508)

概述

  • 产品名称SB 269970 hydrochloride
  • 描述
    Potent, selective 5-HT7 receptor antagonist
  • 生物学描述Potent, selective 5-HT7 receptor antagonist (pKi values are 8.3, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B receptors, respectively). Also potently blocks α2 adrenoceptors. Blocks amphetamine and ketamine induced hyperactivity. Brain penetrant in vivo.
  • 纯度> 98%

性能

    SB 269970 hydrochloride (ab120508)参考文献

    This product has been referenced in:
    • Galici R  et al. Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. Behav Pharmacol 19:153-9 (2008). Read more (PubMed: 18332680) »
    • Roberts C  et al. The effect of SB-269970, a 5-HT(7) receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br J Pharmacol 132:1574-80 (2001). Read more (PubMed: 11264252) »
    • Hagan JJ  et al. Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist. Br J Pharmacol 130:539-48 (2000). Read more (PubMed: 10821781) »

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