概述

  • 产品名称
    SB 216763
  • 描述
    Potent selective GSK3 inhibitor
  • 生物学描述
    Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
  • 纯度
    > 98%

性能

  • 化学名称
    3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • 分子量
    371.22
  • 化学结构
    Chemical Structure
  • 分子式
    C19H12Cl2N2O2
  • CAS编号
    280744-09-4
  • PubChem识别号
    176158
  • 存放说明
    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述
    Soluble in DMSO to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    Clc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23
  • 来源

    Synthetic

  • 研究领域

    SB 216763 (ab120202)参考文献

    This product has been referenced in:
    • Gross ER  et al. Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. Am J Physiol Heart Circ Physiol 294:H1497-500 (2008). Read more (PubMed: 18223186) »
    • Zhu LQ  et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27:12211-20 (2007). Read more (PubMed: 17989287) »
    • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »

    See all 2 Publications for this product

    Product Wall

    Thank you for contacting us.

    Our biochemical compounds are not made in a sterile environment, and as such we would recommend that sterilisation measures are taken prior to use, if a sterile solution is needed.


    I hope this in...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

    注册