概述

  • 产品名称SB 216763
  • 描述
    Potent selective GSK3 inhibitor
  • 生物学描述Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
  • 纯度> 98%

性能

  • 化学名称3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • 分子量371.22
  • 化学结构Chemical Structure
  • 分子式C19H12Cl2N2O2
  • CAS编号280744-09-4
  • PubChem识别号176158
  • 存放说明Store at +4°C. Store under Desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESClc1ccc(c(Cl)c1)C=4C(=O)NC(=O)C=4c3cn(C)c2ccccc23
  • 来源

    Synthetic

  • 研究领域

    SB 216763 (ab120202)参考文献

    This product has been referenced in:
    • Gross ER  et al. Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion. Am J Physiol Heart Circ Physiol 294:H1497-500 (2008). Read more (PubMed: 18223186) »
    • Zhu LQ  et al. Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27:12211-20 (2007). Read more (PubMed: 17989287) »
    • Coghlan MP  et al. Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem Biol 7:793-803 (2000). Read more (PubMed: 11033082) »

    See 1 Publication for this product

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