概述

  • 产品名称Anti-SART3抗体
    参阅全部 SART3 一抗
  • 描述
    山羊多克隆抗体to SART3
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    MSNADFAKLFLRK

    , corresponding to C terminal amino acids 951-963 of Human SART3

  • 阳性对照
    • Lysates of cell lines Daudi, Jurkat and MOLT4.

性能

应用

Our Abpromise guarantee covers the use of ab36137 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明Peptide ELISA: antibody detection limit dilution 1:16,000.
    WB: Use at a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 110 kDa. (predicted molecular weight: 110 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.
    • 组织特异性Ubiquitously expressed.
    • 疾病相关Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900]. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.
    • 序列相似性Contains 8 HAT repeats.
      Contains 2 RRM (RNA recognition motif) domains.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Cytoplasm. Nucleus speckle. Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DSAP1 antibody
      • hSART 3 antibody
      • hSART-3 antibody
      • P100 antibody
      • P110 antibody
      • p110(nrb) antibody
      • RP11 13G14 antibody
      • SART 3 antibody
      • SART-3 antibody
      • SART3 antibody
      • SART3_HUMAN antibody
      • Squamous cell carcinoma antigen recognized by T cells 3 antibody
      • Squamous cell carcinoma antigen recognized by T-cells 3 antibody
      • Tat interacting protein of 110 kDa antibody
      • Tat-interacting protein of 110 kDa antibody
      • Tip110 antibody
      see all

    Anti-SART3 antibody 图像

    Anti-SART3 antibody (ab36137)参考文献

    This product has been referenced in:
    • Long L  et al. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J Biol Chem 289:8916-30 (2014). WB . Read more (PubMed: 24526689) »

    See 1 Publication for this product

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