概述

  • 产品名称Anti-SARM抗体
    参阅全部 SARM 一抗
  • 描述
    兔多克隆抗体to SARM
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids near the C terminus of Human SARM.

  • 阳性对照
    • Human Tonsil tissue.

性能

应用

Our Abpromise guarantee covers the use of ab115561 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 79 kDa.
IHC-P Use a concentration of 2 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
  • 组织特异性Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
  • 序列相似性Contains 2 SAM (sterile alpha motif) domains.
    Contains 1 TIR domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ36296 antibody
    • KIAA0524 antibody
    • MyD88-5 antibody
    • SAM and ARM-containing protein antibody
    • SAM domain-containing protein 2 antibody
    • SAMD2 antibody
    • SARM 1 antibody
    • SARM1 antibody
    • SARM1_HUMAN antibody
    • Sterile alpha and Armadillo repeat protein antibody
    • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila antibody
    • sterile alpha and HEAT/Armadillo motifs-containing protein antibody
    • sterile alpha and TIR motif containing 1 antibody
    • Sterile alpha and TIR motif-containing protein 1 antibody
    • Sterile alpha and TIR motifs-containing protein 1 antibody
    • Sterile alpha motif domain-containing protein 2 antibody
    • Tir-1 homolog antibody
    see all

Anti-SARM antibody 图像

  • ab115561, at 2µg/ml, staining SARM in Formalin-fixed, Paraffin-embedded Human Tonsil tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-SARM antibody (ab115561)参考文献

ab115561 has not yet been referenced specifically in any publications.

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