Anti-SAR1B抗体(ab77279)

概述

  • 产品名称Anti-SAR1B抗体
    参阅全部 SAR1B 一抗
  • 描述
    山羊多克隆抗体to SAR1B
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat
    预测可用于: Human
  • 免疫原

    Synthetic peptide:

    DHERLLESKEELD

    , corresponding to internal sequence amino acids 104-116 of Human SAR1B (NP_001028675.1; NP_057187.1)

  • 阳性对照
    • Mouse and Rat Liver lysate

性能

应用

Our Abpromise guarantee covers the use of ab77279 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: antibody detection limit dilution: 1/8000.
    WB: Use at a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 22 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
    • 组织特异性Expressed in many tissues including small intestine, liver, muscle and brain.
    • 疾病相关Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.
    • 序列相似性Belongs to the small GTPase superfamily. SAR1 family.
    • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ANDD antibody
      • CMRD antibody
      • GTBPB antibody
      • GTP binding protein SAR1b antibody
      • GTP binding protein Sara antibody
      • GTP-binding protein B antibody
      • GTP-binding protein SAR1B antibody
      • SAR1 gene homolog B (S. cerevisiae) antibody
      • SAR1 homolog B antibody
      • SAR1a gene homolog 2 antibody
      • SAR1B antibody
      • SAR1B_HUMAN antibody
      • SARA2 antibody
      • SARB antibody
      see all

    Anti-SAR1B antibody 图像

    Anti-SAR1B antibody (ab77279)参考文献

    ab77279 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"