Anti-SAR1B抗体(ab74046)

概述

  • 产品名称Anti-SAR1B抗体
    参阅全部 SAR1B 一抗
  • 描述
    兔多克隆抗体to SAR1B
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat
  • 免疫原

    Synthetic peptide derived from internal sequence of human SAR1B.

  • 阳性对照
    • Human placenta tissue. Extracts from LOVO and RAW264.7 cells.

性能

应用

Our Abpromise guarantee covers the use of ab74046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).
ELISA 1/20000.
IHC-P 1/50 - 1/100.

靶标

  • 功能Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
  • 组织特异性Expressed in many tissues including small intestine, liver, muscle and brain.
  • 疾病相关Defects in SAR1B are the cause of chylomicron retention disease (CMRD) [MIM:246700]; also known as Anderson disease (ANDD). CMRD is an autosomal recessive disorder of severe fat malabsorption associated with failure to thrive in infancy. The condition is characterized by deficiency of fat-soluble vitamins, low blood cholesterol levels, and a selective absence of chylomicrons from blood. Affected individuals accumulate chylomicron-like particles in membrane-bound compartments of enterocytes, which contain large cytosolic lipid droplets.
  • 序列相似性Belongs to the small GTPase superfamily. SAR1 family.
  • 细胞定位Endoplasmic reticulum membrane. Golgi apparatus > Golgi stack membrane. Associated with the endoplasmic reticulum and Golgi stacks, in particular in the juxta-nuclear Golgi region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ANDD antibody
    • CMRD antibody
    • GTBPB antibody
    • GTP binding protein SAR1b antibody
    • GTP binding protein Sara antibody
    • GTP-binding protein B antibody
    • GTP-binding protein SAR1B antibody
    • SAR1 gene homolog B (S. cerevisiae) antibody
    • SAR1 homolog B antibody
    • SAR1a gene homolog 2 antibody
    • SAR1B antibody
    • SAR1B_HUMAN antibody
    • SARA2 antibody
    • SARB antibody
    see all

Anti-SAR1B antibody 图像

  • All lanes : Anti-SAR1B antibody (ab74046) at 1/500 dilution

    Lane 1 : Extracts from LOVO cells
    Lane 2 : Extracts from RAW264.7 cells
    Lane 3 : Extracts from LOVO cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 22 kDa
    Observed band size : 22 kDa
    Additional bands at : 21 kDa,27 kDa,35 kDa,40 kDa,55 kDa,87 kDa. We are unsure as to the identity of these extra bands.
  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue using ab74046, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-SAR1B antibody (ab74046)参考文献

ab74046 has not yet been referenced specifically in any publications.

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