Anti-Pan-SAPAP抗体(ab67224)
Key features and details
- Rabbit polyclonal to Pan-SAPAP
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
概述
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产品名称
Anti-Pan-SAPAP抗体 -
描述
兔多克隆抗体to Pan-SAPAP -
宿主
Rabbit -
特异性
Please note that the immunogen that generated ab67224 shares some sequence with other SAPAP/DLGAP proteins, including SAPAP1, SAPAP2, and SAPAP4, and preliminary data suggests this antibody may not be specific for SAPAP3.
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经测试应用
适用于: WBmore details -
种属反应性
与反应: Rat -
免疫原
Synthetic peptide corresponding to Human Pan-SAPAP.
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阳性对照
- WB: Rat brain tissue lysate.
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C. -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab67224于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa).
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说明 |
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WB
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 106 kDa (predicted molecular weight: 106 kDa). |
靶标
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相关性
SAPAP3, (DLGAP3) is a member of a protein family whose members specifically interact with PSD-95/SAP90, a membrane-associated guanylate kinase localized at postsynaptic density (PSD) in neuronal cells. Like the other SAPAP proteins, SAPAP3 is thought to be an adaptor protein that also interacts with different synaptic scaffolding proteins, cytoskeletal and signaling components, such as focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2). Both SAPAP3 protein and mRNA are targeted to dendrites, whereas SAPAP1, -2, and -4 mRNAs are detected mainly in cell bodies. Recent experiments have suggested that SAPAP3 may be involved in obsessive-compulsive disorder (OCD), as mice lacking SAPAP3 exhibited OCD-like symptoms which could be relieved by lentiviral-mediated selective expression of SAPAP3 in the striatum of SAPAP3-mutant mice. At least two isoforms are known to exist. -
细胞定位
Cell Membrane -
数据库链接
- Entrez Gene: 286923 Rat
- SwissProt: P97838 Rat
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别名
- DLGAP3 antibody
- DAP3 antibody
- Discs, large (Drosophila) homolog associated protein 3 antibody
see all
图片
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab67224 尚未被引用在任何文献中。