Anti-SAP130抗体(ab114978)
Key features and details
- Rabbit polyclonal to SAP130
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-SAP130抗体
参阅全部 SAP130 一抗 -
描述
兔多克隆抗体to SAP130 -
宿主
Rabbit -
经测试应用
适用于: IPmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Horse, Chicken, Guinea pig, Cow, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan -
免疫原
Synthetic peptide corresponding to Human SAP130 aa 998-1048.
Database link: Q9H0E3 -
阳性对照
- HeLa whole cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8 -
Concentration information loading...
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纯度
Immunogen affinity purified -
纯化说明
ab114978 is affinity purified using an epitope specific to SAP130 immobilized on solid support -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab114978于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
IP |
Use at 2-5 µg/mg of lysate.
|
说明 |
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IP
Use at 2-5 µg/mg of lysate. |
靶标
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功能
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. -
组织特异性
Expressed in various cancer cell ines. -
序列相似性
Belongs to the SAP130 family. -
结构域
The N-terminus may interact with a transcriptional coactivator.
The C-terminus may interact with HDAC-dependent and HDAC-independent corepressors. -
翻译后修饰
Acetylated. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 424756 Chicken
- Entrez Gene: 79595 Human
- Entrez Gene: 269003 Mouse
- Entrez Gene: 307527 Rat
- Omim: 609697 Human
- SwissProt: Q5F3U0 Chicken
- SwissProt: Q9H0E3 Human
- SwissProt: Q8BIH0 Mouse
see all -
别名
- 130 kDa Sin3-associated polypeptide antibody
- FLJ12761 antibody
- Histone deacetylase complex subunit SAP130 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab114978 被引用在 2 文献中.
- Li W et al. The FOXN3-NEAT1-SIN3A repressor complex promotes progression of hormonally responsive breast cancer. J Clin Invest 127:3421-3440 (2017). PubMed: 28805661
- Salas-Armenteros I et al. Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability. EMBO J 36:3532-3547 (2017). PubMed: 29074626