概述

  • 产品名称
  • 描述
    山羊多克隆抗体to SAMSN1
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    IRLDTLSASLGRS-C

    (Human) Please note that the immunogen sequence is present in NP_071419.2 (and in AAK07746) but is no longer present in the latest reference sequence (NP_071419.3 at 05/10/05). This latest version has not been subject to final review by NCBI. This antibody may be recognising one particular isoform.

  • 阳性对照
    • Jurkat lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline. pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab21206 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明
    ELISA: Use at an assay dependent dilution. The antibody detection limit dilution is 1:64,000 in a peptide ELISA.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects a band of approximately 48 kDa in Jurkat cell lysates (predicted molecular weight: 42 kDa). The observed size is consistent with observations with competing products.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation.
    • 组织特异性
      Detected in peripheral blood B-cells (at protein level). Detected in spleen, liver and peripheral blood.
    • 序列相似性
      Contains 1 SAM (sterile alpha motif) domain.
      Contains 1 SH3 domain.
    • 细胞定位
      Nucleus. Cytoplasm. Cell projection > ruffle. Shuttles between cytoplasm and nucleus. Colocalizes with the actin cytoskeleton and actin-rich membrane ruffles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HACS1 antibody
      • Hematopoietic adapter containing SH3 and sterile α motif (SAM) domains 1 antibody
      • Hematopoietic adapter containing SH3 and sterile alpha motif (SAM) domains 1 antibody
      • Hematopoietic adaptor containing SH3 and SAM domains 1 antibody
      • Nash1 antibody
      • Nuclear localization signals SAM and SH3 domain containing 1 antibody
      • SAM and SH3 domain containing 2 antibody
      • SAM domain antibody
      • SAM domain containing protein SAMSN 1 antibody
      • SAM domain SH3 domain and nuclear localisation signals 1 antibody
      • SAM domain SH3 domain and nuclear localization signals 1 antibody
      • SAM domain, SH3 domain and nuclear localization signals protein 1 antibody
      • SAM domain-containing protein SAMSN-1 antibody
      • SAMN1_HUMAN antibody
      • SAMSN 1 antibody
      • Samsn1 antibody
      • SASH2 antibody
      • SH3 domain and nuclear localisation signals 1 antibody
      • SH3 domain and nuclear localization signals protein 1 antibody
      • SH3 SAM adaptor protein antibody
      • SH3-SAM adaptor protein antibody
      • SH3D6B antibody
      • SLy2 antibody
      • Src homology domain 3 (SH3) containing adapter protein SH3 lymphocyte protein 2 antibody
      see all

    图片



    • Predicted band size : 42 kDa


      ab21206 (1 ug/ml) western blot detection of SAMSN1 from Jurkat cell lysate.

    实验方案

    文献

    ab21206 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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