概述

  • 产品名称Anti-SA2抗体
    参阅全部 SA2 一抗
  • 描述
    山羊多克隆抗体to SA2
  • 特异性This antibody is expected to recognize both reported isoforms (NP_001036214.1 and NP_006594.3). Reported variants NP_001036215.1 and NP_001036214.1 represent identical protein: Reported variants NP_001036216.1 and NP_006594.3 represent identical protein.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit
  • 免疫原

    Synthetic peptide:

    SRGSTVRSKKSKPST

    by a Cysteine residue linker, corresponding to internal sequence amino acids 1065-1079 of Human SA2 (NP_001036214.1 and NP_006594.3).

  • 阳性对照
    • K562 lysate.

性能

应用

Our Abpromise guarantee covers the use of ab106788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 160 kDa.

靶标

  • 功能Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • 序列相似性Belongs to the SCC3 family.
    Contains 1 SCD (stromalin conservative) domain.
  • 翻译后修饰Phosphorylated by PLK. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation.
  • 细胞定位Nucleus. Chromosome. Chromosome > centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bA517O1.1 antibody
    • Cohesin Subunit SA 2 antibody
    • Cohesin subunit SA-2 antibody
    • DKFZp686P168 antibody
    • DKFZp781H1753 antibody
    • FLJ25871 antibody
    • SA 2 antibody
    • SA-2 antibody
    • SA2 antibody
    • SCC3 homolog 2 antibody
    • SCC3B antibody
    • STAG 2 antibody
    • stag2 antibody
    • STAG2_HUMAN antibody
    • Stromal antigen 2 antibody
    see all

Anti-SA2 antibody 图像

  • Anti-SA2 antibody (ab106788) at 0.03 µg/ml + K562 lysate at 35 µg

    Predicted band size : 160 kDa

Anti-SA2 antibody (ab106788)参考文献

ab106788 has not yet been referenced specifically in any publications.

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