概述

  • 产品名称Anti-SA2抗体[3C6]
    参阅全部 SA2 一抗
  • 描述
    小鼠单克隆抗体[3C6] to SA2
  • 经测试应用适用于: WB, IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Recombinant Human SA2 Protein (Q8N3U4).

  • 阳性对照
    • Human Breast tissue, Hela nuclear and NIH/3T3 cells extracts and HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab117725 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 141 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 10 µg/ml.

靶标

  • 功能Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • 序列相似性Belongs to the SCC3 family.
    Contains 1 SCD (stromalin conservative) domain.
  • 翻译后修饰Phosphorylated by PLK. The large dissociation of cohesin from chromosome arms during prophase is partly due to its phosphorylation.
  • 细胞定位Nucleus. Chromosome. Chromosome > centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
  • Information by UniProt
  • 数据库链接
  • 别名
    • bA517O1.1 antibody
    • Cohesin Subunit SA 2 antibody
    • Cohesin subunit SA-2 antibody
    • DKFZp686P168 antibody
    • DKFZp781H1753 antibody
    • FLJ25871 antibody
    • SA 2 antibody
    • SA-2 antibody
    • SA2 antibody
    • SCC3 homolog 2 antibody
    • SCC3B antibody
    • STAG 2 antibody
    • stag2 antibody
    • STAG2_HUMAN antibody
    • Stromal antigen 2 antibody
    see all

Anti-SA2 antibody [3C6] 图像

  • Immunohistochemistry Image of Human Breast: Formalin-Fixed, Paraffin-Embedded stained with anti SA2 antibody at 5 µg/ml(ab117725).
  • Anti-SA2 antibody [3C6] (ab117725) + Hela nuclear extracts

    Predicted band size : 141 kDa
  • Anti-SA2 antibody [3C6] (ab117725) + NIH/3T3 protein cell extracts

    Predicted band size : 141 kDa
  • Immunofluorescence of monoclonal antibody to anti SA2 antibody (ab117725) at 10 µg/ml on HeLa cell.

Anti-SA2 antibody [3C6] (ab117725)参考文献

ab117725 has not yet been referenced specifically in any publications.

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