概述

  • 产品名称Anti-RYK抗体
    参阅全部 RYK 一抗
  • 描述
    兔多克隆抗体to RYK
  • 经测试应用适用于: IHC-P, ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to amino acids 576-592 of Human RYK.

  • 阳性对照
    • Jurkat cell lysate.

性能

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应用

Our Abpromise guarantee covers the use of ab5518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100.
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 67.5 kDa (predicted molecular weight: 72 kDa).

靶标

  • 功能May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.
  • 组织特异性Observed in all the tissues examined.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family.
    Contains 1 protein kinase domain.
    Contains 1 WIF domain.
  • 结构域The extracellular WIF domain is responsible for Wnt binding.
  • 翻译后修饰Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation.
  • 细胞定位Membrane. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • D3S3195 antibody
    • ERK 3 antibody
    • Hydroxyaryl protein kinase antibody
    • JTK 5 antibody
    • JTK 5A antibody
    • JTK5 antibody
    • JTK5A antibody
    • JTK5A protein tyrosine kinase antibody
    • receptor like tyrosine kinase antibody
    • receptor like tyrosine kinase precursor antibody
    • RYK 1 antibody
    • Ryk antibody
    • RYK_HUMAN antibody
    • RYK1 antibody
    • Tyrosine protein kinase RYK antibody
    • Tyrosine protein kinase RYK precursor antibody
    • Tyrosine-protein kinase RYK antibody
    • Vik antibody
    see all

Anti-RYK antibody 图像



  • Predicted band size : 72 kDa


    ab5518 at a 1/100 dilution staining approximately 67.5kDa band of RYK in Jurkat cell lysate by Western blot (ECL).
  • ab5518 staining RYK in human hepatocarcinoma (HC) tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-RYK antibody (ab5518)参考文献

ab5518 has not yet been referenced specifically in any publications.

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