功能Enhances the sumoylation of a number of proteins including HIF1A, PIAS and I-kappa-B, through direct interaction with UBC9. Has no effect on ubiquitination.
组织特异性Expressed in a wide number of tissues with highest expression in cerebellum, pituitary, heart, kidney, liver, stomach, pancreas, prostate and spleen. Low levels in thalamus, spinal cord, esophagus, thymus, lung and peripheral blood leukocytes.
序列相似性Contains 1 RWD domain.
结构域The RWD domain is required for the sumoylation enhancement activity.
细胞定位Nucleus. Cytoplasm. Colocalizes with UBC9/UBE2I in nuclear spots.