Anti-RuvC抗体[RuvC 7F1/5] (ab81920)

概述

  • 产品名称Anti-RuvC抗体[RuvC 7F1/5]
    参阅全部 RuvC 一抗
  • 描述
    小鼠单克隆抗体[RuvC 7F1/5] to RuvC
  • 经测试应用适用于: ELISA, WB, IPmore details
  • 免疫原

    Ruv C protein from E. Coli.

性能

应用

Our Abpromise guarantee covers the use of ab81920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution.
IP Use at an assay dependent dilution.

靶标

  • 相关性In Escherichia coli, the RuvA, RuvB and RuvC proteins are required for the late stages of homologous recombination and DNA repair. They are involved in processing the Holliday junction during homologous recombination. RuvA protein binds to both single-stranded and double stranded DNA and enhances ATPase activity of RuvB. RuvA and RuvB promote branch migration whereas RuvC resolves junctions by endonucleolytic cleavage. Moreover RuvAB stimulate Holliday junction resolution by RuvC. The RuvA-RuvB complex interacts with an irregular conformation in damaged DNA and induces conformational changes in DNA using energy provided by ATP hydrolysis, so that it facilitates DNA repair, recombination and error prone replication. RuvABC proteins are responsible for the occurrence of DSBs at arrested replication forks. In cells proficient for RecBC, RuvAB is uncoupled from RuvC and DSBs may be prevented.
  • 别名
    • Crossover junction endodeoxyribonuclease ruvC antibody
    • Holliday junction nuclease ruvC antibody
    • Holliday junction resolvase ruvC antibody

Anti-RuvC antibody [RuvC 7F1/5] (ab81920)参考文献

ab81920 has not yet been referenced specifically in any publications.

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