概述

  • 产品名称Anti-RSK3抗体
    参阅全部 RSK3 一抗
  • 描述
    山羊多克隆抗体to RSK3
  • 特异性ab115037 is expected to recognize both reported isoforms (NP_066958.2; NP_001006933.1).
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse, Horse, Chicken, Cow, Dog, Human, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:

    C-EYLSPNQLSRQDVH

    , corresponding to C terminal amino acids 676-689 of Human RSK3 (NP_066958.2).

  • 阳性对照
    • Rat Lung lysate

性能

应用

Our Abpromise guarantee covers the use of ab115037 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 83 kDa).

靶标

  • 功能Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells.
  • 组织特异性Widely expressed with higher expression in lung, skeletal muscle, brain, uterus, ovary, thyroid and prostate.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • 翻译后修饰Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1.
    N-terminal myristoylation results in an activated kinase in the absence of added growth factors.
  • 细胞定位Nucleus. Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 90 kDa ribosomal protein S6 kinase 2 antibody
    • HU 2 antibody
    • KS6A2_HUMAN antibody
    • MAP kinase activated protein kinase 1c antibody
    • MAP kinase-activated protein kinase 1c antibody
    • MAPK-activated protein kinase 1c antibody
    • MAPKAP kinase 1c antibody
    • MAPKAPK-1c antibody
    • MAPKAPK1C antibody
    • Mitogen.activated protein kinase-activated protein kinase 1C antibody
    • p90 RSK3 antibody
    • p90-RSK 2 antibody
    • p90RSK2 antibody
    • pp90RSK3 antibody
    • Ribosomal protein S6 kinase alpha-2 antibody
    • ribosomal protein S6 kinase, 90kDa, polypeptide 2 antibody
    • Ribosomal S6 kinase 3 antibody
    • RPS6KA2 antibody
    • RSK 3 antibody
    • RSK antibody
    • RSK-3 antibody
    • S6K alpha antibody
    • S6K alpha 2 antibody
    • S6K-alpha-2 antibody
    see all

Anti-RSK3 antibody 图像

Anti-RSK3 antibody (ab115037)参考文献

ab115037 has not yet been referenced specifically in any publications.

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