Anti-Rsk 2 / MAPKAP Kinase 1b抗体(ab90526)

概述

  • 产品名称Anti-Rsk 2 / MAPKAP Kinase 1b抗体
    参阅全部 Rsk 2 / MAPKAP Kinase 1b 一抗
  • 描述
    兔多克隆抗体to Rsk 2 / MAPKAP Kinase 1b
  • 经测试应用适用于: IHC-P, WBmore details
    不适用于: IP
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide, corresponding to a region within the N terminal amino acids 1-50 of Human Rsk 2/ MAPKAP Kinase 1b (NP_004577.1)

  • 阳性对照
    • HeLa, 293T and mouse NIH3T3 whole cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: Tris citrate/phosphate, pH 7-8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab90526 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/500 - 1/2000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/2000 - 1/10000. Predicted molecular weight: 84 kDa.
  • 应用说明Is unsuitable for IP.
  • 靶标

    • 功能Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
    • 组织特异性Expressed in many tissues, highest levels in skeletal muscle.
    • 疾病相关Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
    • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
      Contains 1 AGC-kinase C-terminal domain.
      Contains 2 protein kinase domains.
    • 翻译后修饰Autophosphorylated on Ser-386, as part of the activation process.
      Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 90 kDa ribosomal protein S6 kinase 3 antibody
      • CLS antibody
      • HU 3 antibody
      • HU2 antibody
      • HU3 antibody
      • Insulin stimulated protein kinase 1 antibody
      • Insulin-stimulated protein kinase 1 antibody
      • ISPK-1 antibody
      • ISPK1 antibody
      • KS6A3_HUMAN antibody
      • MAP kinase activated protein kinase 1b antibody
      • MAP kinase-activated protein kinase 1b antibody
      • MAPK activated protein kinase 1b antibody
      • MAPK-activated protein kinase 1b antibody
      • MAPKAP kinase 1b antibody
      • MAPKAPK 1b antibody
      • MAPKAPK-1b antibody
      • MAPKAPK1B antibody
      • Mental retardation, X linked 19 antibody
      • MRX19 antibody
      • OTTHUMP00000023036 antibody
      • p90 RSK2 antibody
      • p90 RSK3 antibody
      • p90-RSK 3 antibody
      • p90RSK3 antibody
      • pp90RSK2 antibody
      • Ribosomal protein S6 kinase 90kDa polypeptide 3 antibody
      • Ribosomal protein S6 kinase alpha 3 antibody
      • Ribosomal protein S6 kinase alpha-3 antibody
      • Ribosomal protein s6 kinase ii alpha 2 antibody
      • Ribosomal S6 kinase 2 antibody
      • Rps6ka3 antibody
      • RSK antibody
      • RSK-2 antibody
      • RSK2 antibody
      • S6 kinase 2 antibody
      • S6K alpha3 antibody
      • S6K-alpha-3 antibody
      see all

    Anti-Rsk 2 / MAPKAP Kinase 1b antibody 图像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling Rsk 2 / MAPKAP Kinase 1b with ab90526 at 1/1000 (1µg/ml). Detection: DAB.
    • All lanes : Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab90526) at 0.4 µg/ml

      Lane 1 : whole cell lysate from HeLa cells at 50 µg
      Lane 2 : whole cell lysate from HeLa cells at 15 µg
      Lane 3 : whole cell lysate from HeLa cells at 5 µg
      Lane 4 : whole cell lysate from 293T cells at 50 µg
      Lane 5 : whole cell lysate from mouse NIH3T3 cells at 50 µg

      Developed using the ECL technique

      Predicted band size : 84 kDa


      Exposure time : 30 seconds

    Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab90526)参考文献

    ab90526 has not yet been referenced specifically in any publications.

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