Anti-Rsk 2 / MAPKAP Kinase 1b抗体(ab76886)

概述

  • 产品名称Anti-Rsk 2 / MAPKAP Kinase 1b抗体
    参阅全部 Rsk 2 / MAPKAP Kinase 1b 一抗
  • 描述
    小鼠单克隆抗体to Rsk 2 / MAPKAP Kinase 1b
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human, Recombinant Fragment
    预测可用于: Cow, Chimpanzee
  • 免疫原

    Recombinant fragment: PLAQLADPWQ KMAVESPSDS AENGQQIMDE PMGEEEINPQ TEEVSIKEIA ITHHVKEGHE KADPSQFELL KVLGQGSFGK VFLVKKISGS DARQ, corresponding to amino acids 2-95 (NP_004577) of Human Rsk 2/ MAPKAP Kinase 1b with a 26kDa tag.

  • 阳性对照
    • HepG2 cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: 1X PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab76886 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 84 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.
  • 组织特异性Expressed in many tissues, highest levels in skeletal muscle.
  • 疾病相关Defects in RPS6KA3 are the cause of Coffin-Lowry syndrome (CLS) [MIM:303600]; an X-linked dominant disorder characterized by severe mental retardation with facial and digital dysmorphisms, and progressive skeletal deformations.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • 翻译后修饰Autophosphorylated on Ser-386, as part of the activation process.
    Ser-227 phosphorylation promotes Ser-386 phosphorylation and leads to basal activation. Full activation by growth factors requires additional phosphorylation on Ser-369.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 90 kDa ribosomal protein S6 kinase 3 antibody
    • CLS antibody
    • HU 3 antibody
    • HU2 antibody
    • HU3 antibody
    • Insulin stimulated protein kinase 1 antibody
    • Insulin-stimulated protein kinase 1 antibody
    • ISPK-1 antibody
    • ISPK1 antibody
    • KS6A3_HUMAN antibody
    • MAP kinase activated protein kinase 1b antibody
    • MAP kinase-activated protein kinase 1b antibody
    • MAPK activated protein kinase 1b antibody
    • MAPK-activated protein kinase 1b antibody
    • MAPKAP kinase 1b antibody
    • MAPKAPK 1b antibody
    • MAPKAPK-1b antibody
    • MAPKAPK1B antibody
    • Mental retardation, X linked 19 antibody
    • MRX19 antibody
    • OTTHUMP00000023036 antibody
    • p90 RSK2 antibody
    • p90 RSK3 antibody
    • p90-RSK 3 antibody
    • p90RSK3 antibody
    • pp90RSK2 antibody
    • Ribosomal protein S6 kinase 90kDa polypeptide 3 antibody
    • Ribosomal protein S6 kinase alpha 3 antibody
    • Ribosomal protein S6 kinase alpha-3 antibody
    • Ribosomal protein s6 kinase ii alpha 2 antibody
    • Ribosomal S6 kinase 2 antibody
    • Rps6ka3 antibody
    • RSK antibody
    • RSK-2 antibody
    • RSK2 antibody
    • S6 kinase 2 antibody
    • S6K alpha3 antibody
    • S6K-alpha-3 antibody
    see all

Anti-Rsk 2 / MAPKAP Kinase 1b antibody 图像

  • Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab76886) at 5 µg/ml + immunogen (recombinant tagged fragment) at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 5000

    Predicted band size : 84 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)
  • Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab76886) at 5 µg/ml + HepG2 cell lysate at 50 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

    Predicted band size : 84 kDa
    Observed band size : 84 kDa

Anti-Rsk 2 / MAPKAP Kinase 1b antibody (ab76886)参考文献

ab76886 has not yet been referenced specifically in any publications.

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