概述

  • 产品名称(RS)-MCPG sodium salt
  • 描述
    Group I /II metabotropic glutamate antagonist; water soluble
  • 生物学描述Group I / group II metabotropic glutamate receptor antagonist. Water soluble form. Also available in Kit: mGlu antagonists (ab120322).

    Also available in simple stock solutions (ab146689) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 纯度> 99%

性能

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    应用

    Our Abpromise guarantee covers the use of ab120252 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    (R,S)-MCPG sodium salt 图像

    • ab17722 staining FMRP in SK-N-SH cells treated with (R,S)-MCPG sodium salt (ab120252), by ICC/IF. Decrease of FMRP expression correlates with increased concentration of (R,S)-MCPG sodium salt, as described in literature.
      The cells were incubated at 37°C for 2h in media containing different concentrations of ab120252 ((R,S)-MCPG sodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab17722 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    (R,S)-MCPG sodium salt (ab120252)参考文献

    This product has been referenced in:
    • Kim JH & Vezina P The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats. Neuropharmacology 37:189-97 (1998). Read more (PubMed: 9680243) »
    • Watkins J & Collingridge G Phenylglycine derivatives as antagonists of metabotropic glutamate receptors. Trends Pharmacol Sci 15:333-42 (1994). Read more (PubMed: 7992387) »
    • Eaton SA  et al. Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine. Eur J Pharmacol 244:195-7 (1993). Read more (PubMed: 8381746) »

    See 1 Publication for this product

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