RS 102895 hydrochloride (ab120812)

概述

  • 产品名称RS 102895 hydrochloride
  • 描述
    Selective CCR2 receptor antagonist
  • 生物学描述Selective CCR2 receptor antagonist (IC50 values are 360 nM and 17.8 μM at CCR2 and CCR1 receptors, respectively). Inhibits MCP-1 and MCP-3 stimulated calcium influx (IC50 values are 32 and 130 nM, respectively). Active in vivo.
  • 纯度> 99%

性能

  • 化学名称1'-[2-[4-(Trifluoromethyl)phenyl]ethyl]spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one hydrochloride
  • 分子量426.86
  • 化学结构Chemical Structure
  • 分子式C21H21F3N2O2.HCl
  • CAS编号1173022-16-6
  • 存放说明Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months.
  • 溶解度概述Soluble in DMSO to 50 mM
  • 处理

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCl.FC(F)(F)c1ccc(cc1)CCN2CCC4(CC2)OC(=O)Nc3ccccc34
  • 来源

    Synthetic

    RS 102895 hydrochloride (ab120812)参考文献

    This product has been referenced in:
    • Rehni AK & Singh N Ammonium pyrrolidine dithiocarbamate and RS 102895 attenuate opioid withdrawal in vivo and in vitro. Psychopharmacology (Berl) 220:427-38 (2012). Read more (PubMed: 21931991) »
    • Rehni AK & Singh TG Involvement of CCR-2 chemokine receptor activation in ischemic preconditioning and postconditioning of brain in mice. Cytokine 60:83-9 (2012). Read more (PubMed: 22704692) »
    • Mirzadegan T  et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275:25562-71 (2000). Read more (PubMed: 10770925) »

    See 0 Publications for this product

    Product Wall

    There are currently no Abreviews or Questions for ab120812.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"