概述

  • 产品名称Anti-RPGRIP1L抗体
    参阅全部 RPGRIP1L 一抗
  • 描述
    山羊多克隆抗体to RPGRIP1L
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: C-

    DKENNKAKRDILK

    , corresponding to internal sequence amino acids 1210-1222 of human RPGRIP1L (NP_056087.2)

  • 阳性对照
    • Human brain (cerebellum) lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris saline, pH 7.3
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab77615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明Peptide ELISA: Use at an assay dependent dilution. Antibody detection limit dilution: 1/64000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 151 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions in kidney cells together with NPHP1 and NPHP4 (By similarity). Does not seem to be strictly required for ciliogenesis.
    • 组织特异性Ubiquitously expressed with relatively high level of expression in hypothalamus and islet. During early development, expressed in multiple organs including brain, eye, forelimb and kidney.
    • 疾病相关Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome, including RPGRIP1L, influence the clinical outcome.
      Joubert syndrome 7
      Meckel syndrome 5
      COACH syndrome
    • 序列相似性Belongs to the RPGRIP1 family.
      Contains 2 C2 domains.
    • 细胞定位Cytoplasm. Cytoplasm > cytoskeleton > cilium basal body. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > microtubule organizing center > centrosome. Cell junction > tight junction. In cultured renal cells, it localizes diffusely in the cytoplasm but, as cells approach confluence, it accumulates to basolateral tight junctions.
    • Information by UniProt
    • 数据库链接
    • 别名
      • CORS 3 antibody
      • CORS3 antibody
      • Fantom antibody
      • FTM antibody
      • FTM_HUMAN antibody
      • JBTS 1 antibody
      • JBTS 7 antibody
      • JBTS1 antibody
      • JBTS7 antibody
      • Joubert syndrome 1 antibody
      • Joubert syndrome 7 antibody
      • Meckel syndrome, type 1 antibody
      • Meckel syndrome, type 5 antibody
      • MKS 5 antibody
      • MKS5 antibody
      • Nephrocystin-8 antibody
      • NPHP 8 antibody
      • NPHP8 antibody
      • Protein fantom antibody
      • Retinitis pigmentosa GTPase regulator interacting protein 1 like antibody
      • RPGR interacting protein 1 like protein antibody
      • RPGR-interacting protein 1-like protein antibody
      • RPGRIP1 like protein antibody
      • RPGRIP1-like protein antibody
      • Rpgrip1l antibody
      see all

    Anti-RPGRIP1L antibody 图像

    • Anti-RPGRIP1L antibody (ab77615) at 0.3 µg + human brain (cerebellum) lysate (in RIPA buffer) at 35 µg
      Developed using the ECL technique

      Predicted band size : 151 kDa
      Observed band size : 151 kDa


      Exposure time : 1 hour

    Anti-RPGRIP1L antibody (ab77615)参考文献

    ab77615 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab77615.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"