概述

  • 产品名称Anti-RPC62抗体
    参阅全部 RPC62 一抗
  • 描述
    鸡多克隆抗体to RPC62
  • 经测试应用适用于: WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Recombinant fragment: HRCY KSIAN LIERR QFET KENKRL LEK SQRVEAI IA SMQATGAE E AQLQEIEEM ITAPERQQLE TLKRNVNKL D ASEIQVDE TI FLLESYI ECT MKRQ, corresponding to amino acids 437-534 of Human RPC62

性能

应用

Our Abpromise guarantee covers the use of ab26185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 61 kDa.
ICC 1/200.

靶标

  • 功能DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
  • 序列相似性Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA directed III 62 kDa polypeptide antibody
    • DNA-directed RNA polymerase III subunit C antibody
    • DNA-directed RNA polymerase III subunit rpc3 antibody
    • POLR3C antibody
    • Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody
    • RNA polymerase C subunit 3 antibody
    • RNA polymerase III 62 kDa subunit antibody
    • RNA polymerase III C62 subunit antibody
    • RNA polymerase III subunit C3 antibody
    • RPC3 antibody
    • RPC3_HUMAN antibody
    • RPC62 antibody
    see all

Anti-RPC62 antibody (ab26185)参考文献

This product has been referenced in:

See 1 Publication for this product

Product Wall

Application Western blot
Sample Human Cell lysate - nuclear (HeLa)
Loading amount 2 µg
Specification HeLa
Treatment formaldehyde 1%, 5 min
Blocking step Tryed: 2% BSA, 5% milk, Roche blocking buffer, Pierce blocking buffer, Millipore special blocking buffer for chicken IgY as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5%
Username

Dr. Svitlana Melnik

Verified customer

提交于 Mar 20 2007

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"