概述

  • 产品名称Anti-RP1抗体
  • 描述
    兔多克隆抗体to RP1
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    antigen sequence, corresponding to amino acids 1254-1400 of Human RP1.

  • 阳性对照
    • Human kidney tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab122781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/2500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Microtubule-associated protein regulating the stability and length of the microtubule-based axoneme of photoreceptors. Required for the differentiation of photoreceptor cells, it plays a role in the organization of the outer segment of rod and cone photoreceptors ensuring the correct orientation and higher order stacking of outer segment disks along the photoreceptor axoneme.
  • 组织特异性Expressed in retina. Not expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, spleen and pancreas.
  • 疾病相关Defects in RP1 are the cause of retinitis pigmentosa type 1 (RP1) [MIM:180100]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性Contains 2 doublecortin domains.
  • 结构域The doublecortin domains, which mediate interaction with microtubules, are required for regulation of microtubule polymerization and function in photoreceptor differentiation.
  • 细胞定位Cytoplasm > cytoskeleton > cilium axoneme. Cell projection > cilium > photoreceptor outer segment. Specifically localized in the connecting cilia of rod and cone photoreceptors.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DCDC4A antibody
    • ORP1 antibody
    • Oxygen-regulated protein 1 antibody
    • Retinitis pigmentosa 1 protein antibody
    • Retinitis pigmentosa RP1 protein antibody
    • RP1 antibody
    • RP1_HUMAN antibody
    see all

Anti-RP1 antibody 图像

  • ab122781, at 1/1000 dilution, staining RP1 in Paraffin Embedded Human kidney tissue by Immunohistochemistry.

Anti-RP1 antibody (ab122781)参考文献

ab122781 has not yet been referenced specifically in any publications.

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