概述

  • 产品名称Anti-RNPS1抗体
    参阅全部 RNPS1 一抗
  • 描述
    小鼠单克隆抗体to RNPS1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: PKPTKVHIGR LTRNVTKDHI MEIFSTYGKI KMIDMPVERM HPHLSKGYAY VEFENPDEAE KALKHMDGGQ IDGQEITATA VL, corresponding to amino acids 158-240 of Human RNPS1

性能

应用

Our Abpromise guarantee covers the use of ab56806 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Part of pre- and post-splicing multiprotein mRNP complexes. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Participates in mRNA 3'-end cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions.
    • 组织特异性Ubiquitous.
    • 序列相似性Belongs to the splicing factor SR family.
      Contains 1 RRM (RNA recognition motif) domain.
    • 翻译后修饰Phosphorylated on one or more of the four Ser/Thr residues (Ser-43, Thr-49, Ser-52 or Ser-53). Ser-53 phosphorylation site is important for splicing and translation stimulation activity in vitro.
    • 细胞定位Nucleus. Nucleus speckle. Cytoplasm. Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E5.1 antibody
      • MGC117332 antibody
      • RNA binding protein S1 serine rich domain antibody
      • RNA binding protein with serine rich domain 1 antibody
      • RNA-binding protein with serine-rich domain 1 antibody
      • RNPS 1 antibody
      • rnps1 antibody
      • RNPS1_HUMAN antibody
      • SR protein antibody
      • SR related protein LDC2 antibody
      • SR-related protein LDC2 antibody
      see all

    Anti-RNPS1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56806 RNPS1 antibody at 1ug/ml. Predicted band size of immunogen is 35 kDa

    Anti-RNPS1 antibody (ab56806)参考文献

    ab56806 has not yet been referenced specifically in any publications.

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