概述

  • 产品名称Anti-RNF7抗体
    参阅全部 RNF7 一抗
  • 描述
    兔多克隆抗体to RNF7
  • 特异性Sufficient sequence differences exist to suggest that this antibody would not react with other RING box proteins such as ROC1 and APC11.
  • 经测试应用适用于: ELISA, Flow Cyt, IP, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide:

    CQQDWVVQRIGK

    conjugated to KLH, corresponding to C terminal amino acids 102-113 of Human RNF7

性能

应用

Our Abpromise guarantee covers the use of ab34873 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/2000 - 1/10000.
Flow Cyt Use at an assay dependent concentration. PubMed: 24786833ab171870-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.
IP Use at an assay dependent concentration.
WB 1/500 - 1/1000. Detects a band of approximately 12.6 kDa (predicted molecular weight: 13 kDa).

靶标

  • 功能Probable component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate. Promotes the neddylation of CUL5 via its interaction with UBE2F. May play a role in protecting cells from apoptosis induced by redox agents.
  • 组织特异性Expressed in heart, liver, skeletal muscle and pancreas. At very low levels expressed in brain, placenta and lung.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the RING-box family.
    Contains 1 RING-type zinc finger.
  • 结构域The RING-type zinc finger domain is essential for ubiquitin ligase activity. It coordinates an additional third zinc ion.
  • 翻译后修饰Phosphorylation by CK2 is required for efficient degradation of NFKBIA and CDKN1B.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CKBBP 1 antibody
    • CKBBP1 antibody
    • CKII beta binding protein 1 antibody
    • CKII beta-binding protein 1 antibody
    • Rbx 2 antibody
    • Rbx2 antibody
    • RBX2_HUMAN antibody
    • Regulator of cullins 2 antibody
    • RING box protein 2 antibody
    • RING finger protein 7 antibody
    • RING-box protein 2 antibody
    • RNF 7 antibody
    • RNF7 antibody
    • ROC 2 antibody
    • ROC2 antibody
    • SAG antibody
    • Sensitive to apoptosis gene antibody
    • Sensitive to apoptosis gene protein antibody
    • Zinc RING finger protein SAG antibody
    see all

Anti-RNF7 antibody (ab34873)参考文献

This product has been referenced in:
  • Chang SC & Ding JL Ubiquitination by SAG regulates macrophage survival/death and immune response during infection. Cell Death Differ N/A:N/A (2014). Flow Cyt . Read more (PubMed: 24786833) »

See 1 Publication for this product

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