概述

  • 产品名称Anti-RNF6抗体
    参阅全部 RNF6 一抗
  • 描述
    小鼠单克隆抗体to RNF6
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE DYRLMRDHNL LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV , corresponding to amino acids 1-101 of Human RNF6

性能

应用

Our Abpromise guarantee covers the use of ab58293 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
    • 组织特异性Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.
    • 通路Protein modification; protein ubiquitination.
    • 疾病相关Defects in RNF6 may be a cause of esophageal cancer (ESCR) [MIM:133239]. A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
    • 序列相似性Belongs to the RNF12 family.
      Contains 1 RING-type zinc finger.
    • 发展阶段Expressed in embryo and adult testis.
    • 细胞定位Nucleus. Cytoplasm. Cell projection > axon. Nucleus > PML body. Localizes to the PML nuclear bodies in Sertoli cells.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E3 ubiquitin-protein ligase RNF6 antibody
      • Ring finger protein (C3H2C3 type) 6 antibody
      • Ring finger protein 6 antibody
      • RING H2 protein antibody
      • RING H2 protein RNF6 antibody
      • RNF 6 antibody
      • RNF6 antibody
      • RNF6_HUMAN antibody
      • SPG2 antibody
      see all

    Anti-RNF6 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab58293 RNF6 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-RNF6 antibody (ab58293)参考文献

    ab58293 has not yet been referenced specifically in any publications.

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