概述

  • 产品名称Anti-RNF41抗体
    参阅全部 RNF41 一抗
  • 描述
    兔多克隆抗体to RNF41
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human RNF41 protein (NP_005776.1).

  • 阳性对照
    • Human kidney tissue lysate; RNF41 transfected 293T cell line lysate

性能

应用

Our Abpromise guarantee covers the use of ab103634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 36 kDa.

靶标

  • 功能Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.
  • 组织特异性Detected in ovary, testis and prostate.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 RING-type zinc finger.
    Contains 1 SIAH-type zinc finger.
  • 翻译后修饰Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 4930511A05Rik antibody
    • 4933415P08Rik antibody
    • E3 ubiquitin protein ligase NRDP1 antibody
    • E3 ubiquitin-protein ligase NRDP1 antibody
    • Fetal Liver RING finger protein antibody
    • FLRF antibody
    • MGC45228 antibody
    • Neuregulin receptor degradation protein 1 antibody
    • NRDP1 antibody
    • RING finger protein 41 antibody
    • rnf41 antibody
    • RNF41_HUMAN antibody
    • SBBI03 antibody
    see all

Anti-RNF41 antibody 图像

  • Anti-RNF41 antibody (ab103634) at 1/500 dilution + Human kidney tissue lysate at 50 µg

    Predicted band size : 36 kDa
  • All lanes : Anti-RNF41 antibody (ab103634) at 1/500 dilution

    Lane 1 : RNF41 transfected 293T cell line lysate
    Lane 2 : Non-transfected 293T cell line lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 36 kDa

Anti-RNF41 antibody (ab103634)参考文献

ab103634 has not yet been referenced specifically in any publications.

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