概述

  • 产品名称Anti-RNF40抗体
    参阅全部 RNF40 一抗
  • 描述
    兔多克隆抗体to RNF40
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between residues 540 and 590 of human RNF40 (NP_055586.1)

  • 阳性对照
    • Human mucinous ovarian carcinoma and human prostate adenocarcinoma tissues.

性能

应用

Our Abpromise guarantee covers the use of ab84515 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). Forms a ubiquitin ligase complex in cooperation with the E2 enzyme UBE2E1/UBCH6. It thereby plays a central role in histone code and gene regulation. Required for transcriptional activation of Hox genes.
    • 组织特异性Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
    • 通路Protein modification; protein ubiquitination.
    • 序列相似性Belongs to the BRE1 family.
      Contains 1 RING-type zinc finger.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 95 kDa retinoblastoma associated protein antibody
      • 95 kDa retinoblastoma protein binding protein antibody
      • 95 kDa retinoblastoma-associated protein antibody
      • BRE 1B antibody
      • BRE1 B antibody
      • BRE1 E3 ubiquitin ligase homolog B antibody
      • BRE1-B antibody
      • BRE1B antibody
      • BRE1B_HUMAN antibody
      • DKFZp686K191 antibody
      • E3 ubiquitin protein ligase BRE1B antibody
      • E3 ubiquitin-protein ligase BRE1B antibody
      • KIAA0661 antibody
      • MGC13051 antibody
      • Rb associated protein antibody
      • RBP 95 antibody
      • RBP95 antibody
      • RING finger protein 40 antibody
      • Ring finger protein 40 E3 ubiquitin protein ligase antibody
      • RNF 40 antibody
      • Rnf40 antibody
      • STARING antibody
      see all

    Anti-RNF40 antibody 图像

    • ab84515 at 1/250 dilution staining RNF40 in human mucinous ovarian carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84515 at 1/250 dilution staining RNF40 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    Anti-RNF40 antibody (ab84515)参考文献

    ab84515 has not yet been referenced specifically in any publications.

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