概述

  • 产品名称Anti-RNF168抗体
    参阅全部 RNF168 一抗
  • 描述
    兔多克隆抗体to RNF168
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    18 amino acid peptide from near the carboxy terminus of Human RNF168 (NP_689830).

  • 阳性对照
    • Human Brain Tissue Lysate

性能

应用

Our Abpromise guarantee covers the use of ab106389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 65 kDa.

靶标

  • 功能E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Defects in RNF168 are the cause of Riddle syndrome (RIDDLES) [MIM:611943]. Riddle syndrome is characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions.
  • 序列相似性Belongs to the RNF168 family.
    Contains 1 RING-type zinc finger.
  • 结构域The MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage.
  • 细胞定位Nucleus. Localizes to sites of DNA damage.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 ubiquitin protein ligase RNF168 antibody
    • E3 ubiquitin-protein ligase RNF168 antibody
    • FLJ35794 antibody
    • FLJ39749 antibody
    • RING finger protein 168 antibody
    • RN168_HUMAN antibody
    • RNF 168 antibody
    • Rnf168 antibody
    see all

Anti-RNF168 antibody 图像

  • Anti-RNF168 antibody (ab106389) at 1 µg/ml + Human Brain Tissue Lysate at 15 µg

    Predicted band size : 65 kDa

Anti-RNF168 antibody (ab106389)参考文献

ab106389 has not yet been referenced specifically in any publications.

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