概述

  • 产品名称
  • 描述
    兔多克隆抗体to RNF156
  • 经测试应用
    适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to a region between amino acids 505-555 of Human RNF156 (NP_001135761.1).

  • 阳性对照
    • HeLa whole cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab101997 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明
    Is unsuitable for WB.
  • 靶标

    • 功能
      E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination.
    • 通路
      Protein modification; protein ubiquitination.
    • 序列相似性
      Contains 1 RING-type zinc finger.
    • 结构域
      The RING finger is required for ubiquitin ligase activity.
    • 翻译后修饰
      Autoubiquitinated in vitro.
    • 细胞定位
      Cytoplasm > cytosol. Cell membrane; Early endosome. The endosomal localization is dependent on the interaction with TSG101 and Cytoplasm > cytosol. Nucleus. Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
    • Information by UniProt
    • 数据库链接
    • 别名
      • E3 ubiquitin-protein ligase MGRN1 antibody
      • KIAA0544 antibody
      • Mahogunin ring finger 1 antibody
      • Mahogunin RING finger protein 1 antibody
      • MGRN 1 antibody
      • Mgrn1 antibody
      • MGRN1_HUMAN antibody
      • Probable E3 ubiquitin protein ligase MGRN1 antibody
      • RING finger protein 156 antibody
      • RNF 156 antibody
      see all

    文献

    ab101997 has not yet been referenced specifically in any publications.

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