概述

  • 产品名称Anti-RNF139抗体
    参阅全部 RNF139 一抗
  • 描述
    小鼠单克隆抗体to RNF139
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: HYFHALCLRK WLYIQDTCPM CHQKVYIEDD IKDNSNVSNN NGFIPPNETP EEAVREAAAE SDRELNEDDS TDCDDDVQRE RNGVIQHTGA AAEEFNDDTD , corresponding to amino acids 565-665 of Human RNF139

性能

应用

Our Abpromise guarantee covers the use of ab56924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
IHC-P
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性RNF139 is a multi-membrane spanning protein E3 ubiquitin ligase which is mutated in clear-cell renal carcinomas. It contains a sterol-sensing domain and a RING-H2 motif essential for ubiquitin ligase activity. It is a potential tumor suppressor for renal cell carcinoma. Human kidney cells are growth inhibited by RNF139. Inhibition is manifested by G2/M arrest and is dependent upon the ubiquitin ligase activity of the RING domain. Expression of RNF139 represses genes involved in cholesterol and fatty acid biosynthesis that are transcriptionally regulated by the sterol response element binding proteins (SREBPs). RNF139 modulation of SREBP activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway.
    • 细胞定位Endoplasmic reticulum membrane; Multi-pass membrane protein.
    • 数据库链接
    • 别名
      • E3 ubiquitin-protein ligase RNF139 antibody
      • HRCA1 antibody
      • RCA1 antibody
      • Ring finger protein 139 antibody
      • Translocation in renal carcinoma on chromosome 8 protein antibody
      • TRC8 antibody
      see all

    Anti-RNF139 antibody 图像

    • RNF139 antibody (ab56924) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.


    • Predicted band size : 76 kDa
      RNF139 antibody (ab56924) at 1ug/lane + HepG2 cell lysate at 25ug/lane.

    Anti-RNF139 antibody (ab56924)参考文献

    This product has been referenced in:
    • Gimelli S  et al. The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. Mol Cancer 8:52 (2009). IHC-P ; Human . Read more (PubMed: 19642973) »

    See 1 Publication for this product

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