概述

  • 产品名称Anti-RNF12抗体
    参阅全部 RNF12 一抗
  • 描述
    兔多克隆抗体to RNF12
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 1 - 50 (MENSDSNDKG SGDQSAAQRR SQMDRLDREE AFYQFVNNLS EEDYRLMRDN) of Human RNF12 (NP_057204).

  • 阳性对照
    • HT1080 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab97838 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 68 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
  • 组织特异性Expressed in many tissues.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Belongs to the RNF12 family.
    Contains 1 RING-type zinc finger.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • E3 ubiquitin-protein ligase RLIM antibody
    • LIM domain-interacting RING finger protein antibody
    • R-LIM antibody
    • Renal carcinoma antigen NY-REN-43 antibody
    • RING finger LIM domain-binding protein antibody
    • RING finger protein 12 antibody
    • RLIM antibody
    • RNF12 antibody
    • RNF12_HUMAN antibody
    see all

Anti-RNF12 antibody 图像

  • Anti-RNF12 antibody (ab97838) at 1 µg/ml (in 5% skim milk / PBS buffer) + HT1080 cell lysate

    Secondary
    HRP-conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 68 kDa

Anti-RNF12 antibody (ab97838)参考文献

ab97838 has not yet been referenced specifically in any publications.

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