Anti-RNA Helicase A抗体(ab84499)

概述

  • 产品名称Anti-RNA Helicase A抗体
    参阅全部 RNA Helicase A 一抗
  • 描述
    兔多克隆抗体to RNA Helicase A
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee, Gorilla, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region between residues 1220 and the C-terminus (residue 1270) of Human RNA Helicase A (CAA71668.1).

  • 阳性对照
    • Human stomach adenocarcinoma. Mouse squamous cell carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab84499 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Unwinds double-stranded DNA and RNA in a 3' to 5' direction. Alteration of secondary structure may subsequently influence interactions with proteins or other nucleic acids. Functions as a transcriptional activator. Component of the CRD-mediated complex that promotes MYC mRNA stability.
    • 序列相似性Belongs to the DEAD box helicase family. DEAH subfamily.
      Contains 2 DRBM (double-stranded RNA-binding) domains.
      Contains 1 helicase ATP-binding domain.
      Contains 1 helicase C-terminal domain.
    • 结构域The MTAD domain mediates interaction with the RNA polymerase II holoenzyme. The NTD domain is necessary and sufficient for nucleo-cytoplasmic shuttling and interaction with HRMT1L2 and SMN1.
    • 翻译后修饰Methylated. HRMT1L2 mediated methylation of undefined Arg residues in the NTD is required for nuclear localization.
      May be phosphorylated by PRKDC/XRCC7. Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus > nucleolus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Can shuttle between nucleus and cytoplasm.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ATP dependent RNA helicase A antibody
      • ATP-dependent RNA helicase A antibody
      • DDX 9 antibody
      • DDX9 antibody
      • DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 antibody
      • DEAD/H box 9 antibody
      • DEAD/H box polypeptide 9 antibody
      • DEAH (Asp Glu Ala His) box polypeptide 9 antibody
      • DEAH box polypeptide 9 antibody
      • DEAH box protein 9 antibody
      • DHX 9 antibody
      • dhx9 antibody
      • DHX9_HUMAN antibody
      • Leukophysin antibody
      • LKP antibody
      • NDH 2 antibody
      • NDH II antibody
      • NDH2 antibody
      • NDHII antibody
      • Nuclear DNA helicase II antibody
      • RHA antibody
      see all

    Anti-RNA Helicase A antibody 图像

    • ab84499, at 1/250 dilution, staining RNA Helicase A in formalin-fixed, paraffin-embedded human stomach adenocarcinoma by Immunohistochemistry, using DAB staining.
    • ab84499, at 1/250 dilution, staining RNA Helicase A in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry, using DAB staining.

    Anti-RNA Helicase A antibody (ab84499)参考文献

    ab84499 has not yet been referenced specifically in any publications.

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